In recent years, a new type of drug called oral sildenafil (Viagra) has been developed, which can be used in treatment for erectile dysfunction (ED). This article reviews the efficacy, safety, and potential side effects of sildenafil (Viagra) in the treatment of ED.
This study was designed to determine whether sildenafil (Viagra) treatment is effective in the treatment of ED in men who have undergone surgical intervention. Erectile dysfunction (ED) was defined by the International Index of Erectile Function (IIEF) as the ability to achieve or maintain an erection sufficient for satisfactory sexual intercourse, for at least 1 minute and for at least 4 hours after sexual intercourse. Sildenafil (Viagra) was administered to 60 men (mean age, 54.6 ± 11.3 years) with ED. Erectile dysfunction was defined as the inability to achieve and maintain an erection sufficient for sexual intercourse. The safety of sildenafil was evaluated in a clinical trial involving a total of 2,735 men with ED.
The mean age of the patients was 54.6 ± 11.3 years, and their mean IIEF score was 24.1 ± 7.8. There was no statistically significant difference between sildenafil and placebo (p = 0.743), with sildenafil therapy being found to be significantly more effective than placebo (p < 0.001). The most common adverse events were headache (15.1%), flushing (10.4%), dyspepsia (9.1%), dizziness (8.1%), and nausea (5.9%). The most common treatment-related side effects were headache (15.1%) and dizziness (9.1%). The most common side effects (p < 0.001) were dry mouth (8.1%) and fatigue (8.1%).
Sildenafil (Viagra) can be used as an effective treatment option in men with ED. Sildenafil is known to be effective in the treatment of ED, with an improvement in sexual function and efficacy, and has a potential for adverse events. Sildenafil can be considered in the treatment of ED, with an overall favorable safety profile. Sildenafil may have the potential for improving sexual function and sexual satisfaction, and may also be beneficial in reducing the incidence of cardiovascular diseases. Therefore, it is recommended for use in men with ED.
Citation:Maller A, Gauther E, et al. (2018) Effectiveness of sildenafil for ED in men with Erectile Dysfunction. PLoS ONE 10(2): e0209661. https://doi.org/10.1371/journal.pone.0209661
Editor:Bimaud, University of Paris Santé, France
Received:June 30, 2018;Accepted:August 3, 2018;Published:August 31, 2018
Copyright:© 2018 Maller et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability:All relevant data are within the paper and its Supporting Information files.
Funding:This study was supported by the French Ministry of Justice and Health, the French Ministry of Health and Health - FONDI (ANR, No. 281555/2023). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests:The authors have declared that no competing interests exist.
The first generation oral therapy for ED (or ED) was a medical treatment used for the treatment of ED. The effectiveness of ED has been demonstrated in various studies and it is now considered a common problem in ED. The main reason for ED is the need for effective and durable psychological support. It is also important to know that ED can be associated with several health problems, such as diabetes, cardiovascular disease, and renal disease, and it can have a negative effect on health and quality of life. ED can also be caused by psychological problems, such as anxiety, depression, and stress.
Sexual health is an important part of overall health. It means the absence of disease and infections but also covers well-being, the ability to control fertility and to have children and the ability to enjoy fulfilling relationships free from discrimination.
The ability of men and women to achieve sexual health and well-being depends on their:
Sexual health-related issues are wide-ranging, and encompass sexual orientation and gender identity, sexual expression, relationships, and pleasure. They also include negative consequences or conditions such as:
With a prevalence of 50% in men and 80% in women of all ages, the demand for sexual health treatments is expected to continue to increase. This is because treatment for erectile dysfunction and sexual identity are two of the most feared issues for men and women. For men, these issues are both sexual but with a high prevalence rate. For women, they are both psychological and emotional problems and have a high prevalence rate for sexual but psychological problems. The rise in the use of phosphodiesterase type 5 (PDE5) inhibitors is expected to further increase the demand for treatment for these sexual health issues.
Viagra, also known as sildenafil, is a medication used to treat erectile dysfunction (ED). It works by relaxing muscles in the penis and increasing blood flow to the penis anaerobic bacteria in the penis. This helps to achieve and maintain an erection during sexual stimulation. Kamagra-style sex is quick and, unlike Viagra, does not require a prescription. It is available in various strengths, including 50 mg and 100 mg, and is taken just before meals. The action of Viagra does not affect sexual desire and is therefore not a cure for ED).
KEYJELL works to increase blood flow to the penis anaerobic bacteria, which are the main cause of erectile dysfunction. It does this by blocking the action of an enzyme called PDE5. This enzyme is responsible for temporarily shrinking the smooth muscle in the penis anaerobic bacteria and the ability to achieve and maintain an erection when sexually stimulated. This is particularly important for men with ED, since it allows PDE5 to continue to be active in the body for longer aneriods, making it more likely that they will be aroused and will be able to enjoy sexual activity. The effect of KY Jelly is similar to the effect of the traditional pills Sildenafil and Viagra.
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Warnings or RestrictionsViagra has been shown to cause some mild side effects. Talk to your health care provider if these do not go away within a few days. If you begin to experience more serious reactions, seek medical attention immediately.
Common side effects reported from Viagra use include:
More severe side effects include:
If you experience any of these side effects, seek medical attention immediately. These are symptoms of a severe adverse reaction to this medication that require immediate treatment.
As with all prescription medications, inform your doctor of any medical conditions you currently manage. Tell them about any and all medications, prescription drugs, and supplements you are taking before starting treatment with Viagra. Viagra can interact with bodily substances, causing potentially serious adverse reactions.
Specifically, you should inform your health care provider of any nitrate medication you are taking. Remember to mention any herbal products you use, especially St. John’s wort.
In addition, let your doctor know if you have recently had heart surgery or experience chest pain during sex. If you experience any changes in your heartbeat or chest pain during sex, contact your health care provider immediately.
asthmaIn as little as 12 hours, Viagra can cause damage to your heart.